Extrinsic noise effects on ribosomal traffic during the translation process

Abstract Any cellular process at the microscopic level is governed by both extrinsic and intrinsic noise (IN) same true for mRNA translation as well. Even though effect of stochasticity via IN well studied translation, cannot be said about (EN). In this article, we incorporate EN in a model carry out stochastic simulations same. We then evaluate various statistics related to residence time ribosome ribosomal traffic on subsequent protein production. also study slow codons dropoff. From our simulations, show that initiation rate rather than termination acts significantly broaden distribution times lattice. This has an current, density Further, presence increase mean times. However, depends number position act mask any from themselves. Our results, therefore, have implications towards better understanding role individual components play during process.